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This means the immune system, the bodys defence against infection, goes wrong and attacks healthy tissue. The most popular theory is that the immune system mistakes harmless bacteria inside the colon for a threat and attacks the tissues of the colon, causing it to become inflamed. Standard treatment for ulcerative colitis depends on the extent of involvement and disease severity. The goal is to induce remission initially with medications, followed by the administration of maintenance medications to prevent a relapse. The concept of induction of remission and maintenance of remission is very important. The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. Until the development of the ileal pouch-anal anastomosis (ipaa) in the early 1980s, total proctocolectomy with end ileostomy (tpc) was the only definitive surgery for ulcerative colitis and colectomy with ileorectal anastomosis (ira) (fig. 1) was the procedure of choice for affected patients who needed surgery, but were reluctant to have a permanent ileostomy. Ulcerative colitis affects your colon, which is part of your digestive system. A lot of things can cause trouble in that general area, so how do you know what it feels like to have ulcerative. Anal pain can occur before, during, or after a bowel movement. It can range from a mild ache that can get worse over time to pain that is bad enough to restrict daily activities. Anal pain has many causes, most of which are common and treatable. Ulcerative colitis (uc) is an inflammatory bowel disease that affects your large intestine, causing irritation, inflammation, and ulcers in the colon. They may be used to treat adults with moderate to severe ulcerative colitis if other options are not suitable or working. Infliximab may also be used to treat children or young people aged 6 to 17 with severe ulcerative colitis. The treatment is given for 12 months unless the medicine is not working well.   even if the era for biological therapy for inflammation bowel disease (ibd) has arrived, restorative proctocolectomy with ileal pouch-anal anastomosis (ipaa) is still the surgical treatment of choice for the majority of patients with ulcerative colitis (uc) who fail medical therapy or develop dysplasia or neoplasia as well as for patients with familial adenomatous polyposis (fap).

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